Ultima-Selank 5mg

MANUFACTURER
Ultima Pharmaceuticals - US
WAREHOUSE
USA Warehouse 5
SUBSTANCE
Selank

For safety reasons, our products are shipped without brand labels. The rapid advancements in biotechnology have opened doors to innovative biologically-active substances, including exciting "cognitive enhancers" or "nootropics." One standout in this realm is Selank, previously known as "TP-7." This synthetic peptide, a small, artificially created protein, is gaining attention for its potential benefits.

Selank is touted as an effective anti-anxiety agent that may enhance learning and boost energy levels, all without the risks associated with side effects or addiction. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences) in collaboration with the V.V. Zakusov Research Institute of Pharmacology, Selank is significantly smaller than most naturally occurring proteins.

This innovative compound was crafted by combining a peptide known as tuftsin, which is naturally present in the body as part of the IgG antibody, with another sequence that enhances its stability. Both tuftsin and Selank have demonstrated the ability to reduce anxiety and elevate serotonin levels in animal studies, with Selank showing even greater effectiveness.

In Russia, Selank is approved for treating generalized anxiety disorder (GAD) and is also recognized for its nootropic properties. While it hasn't received FDA approval for any medical conditions, Selank remains accessible in various markets, often promoted as a "nutritional supplement."

Mechanism of Action of Selank
Although the exact mechanisms of Selank are still under investigation, it is believed to play a role in stabilizing enkephalins in the bloodstream?natural peptides that help mitigate the stress response. Some studies suggest that Selank may interact with GABA receptors, which are associated with calming effects. Research in mice showed that Selank increased activity in GABA-dependent inhibitory neurons, resulting in decreased overall brain activity, which aligns with sedative effects.

Additionally, Selank has been linked to an increase in BDNF, a vital neurotrophic factor associated with learning and memory, potentially explaining some of its cognitive benefits. It has also been shown to influence levels of neurotransmitters such as norepinephrine, dopamine, and serotonin?key players in motivation, focus, and pleasure.

One animal study found that Selank increased norepinephrine while decreasing dopamine and serotonin levels, while in other scenarios, it elevated both norepinephrine and dopamine without affecting serotonin. This variability highlights the need for further research to clarify its specific effects and mechanisms.

Potential Effects
In a preliminary clinical trial with 62 participants, those who received Selank reported reduced anxiety symptoms, especially among individuals with existing anxiety disorders. Another study involving 60 anxious patients revealed similar benefits, lasting up to a week after the last dose. A third trial with 70 anxiety patients noted that Selank could enhance the effects of phenazepam (an anti-anxiety medication banned in some U.S. states) while reducing adverse effects like drowsiness and memory impairment.

Anxiety
Animal studies have demonstrated Selank's ability to decrease anxiety in mice, particularly in those that were more anxious, with significant behavioral improvements post-treatment. While evidence remains limited, it suggests Selank may help alleviate anxiety; further investigation is crucial for validating its efficacy and safety in humans. If you experience anxiety, consult your doctor about the potential benefits of Selank, but remember it should not replace prescribed treatments.

In a 30-day study, Selank was shown to stabilize memory traces in rats, potentially enhancing memory retention. Another study indicated that Selank might help preserve memory in monkeys.

Memory
Currently, human studies are lacking, leaving the effects of Selank on healthy individuals uncertain. Its long-term safety remains to be established, so caution is advised until more research is conducted.

Research indicated that in rats with toxin-induced brain damage, Selank administration normalized brain activity.

Brain Damage Recovery
Selank also appeared to reduce depressive symptoms in mice, showing greater effectiveness at lower doses compared to higher ones.

Depression
In one preliminary animal study, Selank injections resulted in increased antioxidant levels in the livers of stressed mice.

Antioxidant Activity in the Liver
In studies with sedated cats, Selank was found to lower blood pressure by approximately 30% for up to three minutes and enhance brain blood flow by about 24% for up to ten minutes. While these initial findings imply temporary cardiovascular effects, their significance and strength remain uncertain, especially since these observations were limited to animals.

Blood Flow
Anxiety is a common symptom during alcohol withdrawal. In a study simulating high alcohol intake, rats administered Selank reportedly experienced alleviated anxiety symptoms following a 48-hour withdrawal period.

Alcohol Withdrawal
An animal study indicated that rats on a high-fat diet treated with Selank gained 35% less weight, with total cholesterol levels dropping by over 58% and blood glucose levels decreasing by 23.5%.

Weight Management and Cholesterol Reduction
In another study, breast cancer-affected mice receiving daily doses of Selank exhibited slower tumor growth and longer lifespans than untreated mice. However, these findings do not confirm any anticancer efficacy of Selank, and extensive research is needed before considering it as a viable cancer treatment option.

Cancer
Post-treatment with Selank revealed increased levels of several inflammatory response genes in the spleens of mice, suggesting potential protective benefits against inflammation.

Inflammation in the Spleen
Selank has been shown to reduce the area of stomach ulcers in animal models, possibly by enhancing lymph flow to the stomach, a crucial aspect of immune function. Nevertheless, comprehensive human studies are required to validate these effects and their underlying mechanisms.

Ulcers
Selank was reported to elevate IL-6 levels in blood cells from patients with depression. IL-6 is an inflammatory protein that may support infection resistance. Additionally, in one cell-based study, Selank stimulated the release of interferons, molecules that combat viruses.

Immune Function
There are suggestions that Selank could provide protection against certain viral infections, although results from an animal study involving virus-infected mice have raised questions about these antiviral benefits. Further research is essential to fully evaluate Selank's potential and limitations.