ACTIVE HALF-LIFE
24 hours
CLASSIFICATION
Combination Antibiotic / Macrolide, Gastrointestinal Agent / Miscellaneous
DOSAGE
1530 mg/day
ACNE
Not Applicable
WATER RETENTION
Not Applicable
HBR
Not Applicable
HEPATOTOXICITY
Low Risk
AROMATIZATION
Not Applicable
MANUFACTURER
Deva
WAREHOUSE
International Warehouse 2
SUBSTANCE
Amoxicillin, Clarithromycin, Lansoprazole
What is Trio?
Trio is expertly formulated for the effective treatment and prevention of gastrointestinal (GI) ulcers caused by infection.
Essential Information to Discuss with Your Healthcare Provider Before Using Trio
- Notify your doctor if you have allergies to lansoprazole, amoxicillin, clarithromycin, any penicillin, or any other ingredients in these medications.
- Share any known allergies to other medications, foods, or substances, and describe any related symptoms you may have experienced, such as rashes, hives, or difficulty breathing.
- Inform your doctor about any history of liver issues related to these medications.
- Disclose if you have had a prolonged QT interval on an ECG or any irregular heart rhythms.
- Let your doctor know if you have low magnesium or potassium levels, or a slow heart rate.
- Mention any kidney or liver disease if you are taking colchicine.
- Discuss any other medications (both prescription and over-the-counter), natural products, or vitamins that might interact with lansoprazole, amoxicillin, and clarithromycin, especially those for high cholesterol, migraines, or mental health conditions.
- If you are taking medications that may cause abnormal heart rhythms (prolonged QT interval), consult your doctor or pharmacist.
- Notify your healthcare provider if you are currently breastfeeding or plan to breastfeed.
Key Considerations While Taking Trio
- Serious allergic reactions may occur rarely. Contact your doctor if you have any concerns.
- Seek medical attention if you experience throat pain, chest pain, severe abdominal discomfort, difficulty swallowing, or symptoms of a bleeding ulcer, including black or bloody stools and vomiting blood.
- Avoid alcohol consumption while on this medication.
- Long-term use may increase the risk of fractures in individuals with osteoporosis. Discuss this risk with your healthcare provider, especially if you are over 50.
- Low magnesium levels have been reported in some patients using this medication long-term. Regular blood tests may be required, particularly if you are on other medications like digoxin or diuretics.
- Watch for signs of severe liver issues, including dark urine, fatigue, loss of appetite, stomach pain, pale stools, vomiting, or jaundice, and seek immediate medical attention if they occur.
- Irregular heart rhythms (long QT interval) may develop, especially when combined with other drugs. Seek help if you notice irregular heartbeats.
- Lupus has been associated with this medication or may worsen pre-existing lupus. Inform your doctor if you have lupus and report any symptoms like facial rash or joint pain.
- In rare cases, serious reactions may manifest with fever, rash, swollen glands, and organ-related issues. Consult your doctor about any such reactions.
- If you have heart disease, let your doctor know, as some studies suggest an increased mortality risk with clarithromycin.
- Individuals aged 65 and older should exercise caution, as they may be more susceptible to side effects.
- This medication may reduce the effectiveness of hormonal birth control. Consider additional contraceptive measures while on Trio.
- Trio can pose risks to an unborn child if taken during pregnancy. Contact your doctor if you become pregnant or plan to conceive while using this medication.
Recommended Administration of Trio
Adhere strictly to your doctor?s instructions regarding the use of lansoprazole, amoxicillin, and clarithromycin. Follow all guidance closely to maximize benefits.
- Ensure you do not miss doses to gain the most from your treatment.
- Continue taking the medication as directed, even if you start to feel better.
- Take the medication before meals for optimal absorption.
- If using sucralfate, take lansoprazole, amoxicillin, and clarithromycin at least 30 minutes prior.
- Inform all healthcare providers, including doctors, nurses, pharmacists, and dentists, about your use of these medications.
- For diabetes management, avoid Clinitest? and use alternative urine glucose tests like Clinistix? or Tes-Tape?.
- This medication may influence certain lab tests, so be sure to inform your healthcare providers and lab personnel.
- Regularly monitor your blood work as advised by your doctor and maintain open communication.
- Discuss with your doctor if you are taking other medications that may require closer monitoring of your blood levels.
- Exercise caution if you have conditions that can lead to fragile bones (osteoporosis); discuss your risk factors with your doctor.